Genentech insists it hasn't lost its R&D mojo

Roche's battle to preserve and protect Genentech's research culture includes a full court press to convince BusinessWeek that the pharma giant is doing everything in its power to sustain an R&D culture with a stellar track record. That means everything from an independent budget to a commitment to maintain review Wednesdays for presentations to management and those relaxed after-work parties on Friday.

"We have a budget and a completely independent [drug] portfolio that we manage, irrespective of the rest of Roche," Richard Scheller, Genentech's head of research, tells the magazine. Researchers in Basel, Switzerland and South San Francisco are being encouraged to stay independent, in marked contrast to the radical restructuring underway at Pfizer. And Scheller says that Roche's approach is making it easier to push new drug programs with diagnostic tests. "Now there's no intellectual-property discussion, there's no negotiation--we're the same!" Scheller says. "You wouldn't believe how much easier it is."

There are no discouraging words of doubts or behind-the-scenes drama to mar the picture presented in the magazine. Not even a mention of the departure of top execs like Dr. Susan Desmond-Hellmann or Roche's efforts to streamline costs in South San Francisco. Whatever is happening inside Genentech, it can check off its latest high profile close-up as a clear PR win.

- read the article in BusinessWeek

Biological Physics Seminar - Fall 2009

"Pulling single biomolecules apart: Observations and Theory"

Olga Dudko

Univ. of California at San Diego
Date: Wednesday, December 2, 2009
Location: Biodesign B105
Time: 4:00 - 5:00 pm
Host: Robert Ros
Recent advances in biophysical techniques enable experimentalists to exert forces on individual molecules and observe their response in real time. With the spectacular resolution of piconewton forces and sub-nanometer distances, single-molecule manipulation experiments reveal details that are typically lost to ensemble averaging when studied by traditional \"bulk\" methods. However, interpretation of the experimental observables in terms of the underlying molecular interactions and structures is a challenging task. I will present a theory of single-molecule force spectroscopy, and illustrate the use of the theory by analyzing the nanopore unzipping of individual DNA hairpins, unfolding of single protein molecules with an atomic force microscope, and other experiments.


Vapour-Natty Rocker
Jaydan-Sometin for the man dem
Q-Project-Jungle is Dead
Ray Keith – Silver Lion (dub)
Cool Hand Flex -Must Feel (Serum rmx)
Rufige Kru – Special Request – Metalheadz
Theory – Jungle – ??
Ray Keith – Sing Time – (Explicit rmx) dub
Jaydan -Ghetto – Ganja Dub
Dark Soldier Vs Bladerunner – Terror Soldier – Dub
Goldie – Chico Death of a Rockstar – FFRR
Optical – The Shining (Ed + Optical Rmx)
Omni Trio – Renegade Snares (Bladerunner Rmx) – Dub
Spirit – 1471 – Inneractive
Dego, Randall and Goldie – The R (Jay Jay & Marc C Rmx)
Hades – The Break – 36 Hertz
Miracle – Universal – (Menacer Rmx) – miraculous
Bailey & ShyFX – Lion Sound – Dub
Spinback – Execution (Serum Rmx)
Johnny L – Harry – Mr L
Lennie De Ice – We R IE (DJ Vapour Rmx) – Stepback Vol 1

Hudson Mohawke take to the decks for Radio 1’s Essential Mix. Download here


Loops Haunt – Dusk Mechanics
Machine Drum – Sakatak
Red – I should tell ya momma on you
Hudson Mohawke – Bopgunn V1 Instrumental
Dorian Concept & Lil Filip – I’m A Balla [Patchwork Pirates Edit]
Hudson Mohawke – Fuse
Tiago – Babelfish
Rustie – Nekoo
Starkey – Ok Luv
Hudson Mohawke – Ice Viper
Hudson Mohawke – Overnight Celebrity
Hudson Mohawke – Start of A Story
Hudson Mohawke – Are You Feeling Hot
Hudson Mohawke – Take my hand
Hudson Mohawke – Still on it
Hudson Mohawke – Pipes
Hudson Mohawke – Chorduroy
Hudson Mohawke – Photo 2
Hudson Mohawke – Waldo’s Gift
Harmonic 313 – Scar (ft. Wiley)
Princess – Say Im your number one
Markis Sage – Creature of Lagoon
Redinho – Mo Brap
Krystal Klear – Boogie Wan
Midnight Star & Usher – Touch that midas Girl
Becoming Real – Get Hype
Free School – Grey Goose (ft. Kelis)
Ludacris – How low can you go
Redhino – Banger
Hudson Mohawke – Stay Fresh
Lazersword – Trapperkeeper
Lil Wayne – I Feel like dying [Flying Lotus remix]
KGB Man – Africa
Ply Firls – I Could Give You Reasons
James Pants – Lickin”Stick
Hudson Mohawke – Twistclip Loop
Carl Cox – Let’s do it
Apple – Die Siegalizer
DJ Seduction – Imp002
Becoming Real – New Kids
Manix – Heads in the clouds
Jjak Hogan – Frequency
Machindrum – Carry the Weight
Fatima Yamaha – What’s a girl to do
Nacho Patrol – Futuriscic Abeba [Hudson Mohawke Remix)
Slum Villega - Dirty [ft. ODB)
The Pharcyde - Passin Me By [FlyAsPie Remix]
Cloud One & Madlib – Unknown Interlude Track
SciFi Stu – The Will (ft. Vast Aire)
Terror Danjah – Bipolar
Joy Orbison – J.Doe
Lone – Sharpest View of the sun
Mwëslee – Eurocame Snips Track 4
Hudson Mohawke – Monde
Mike SLott – Snow Birds
Dimilite – Cotdam [ft. Pharrell]
American Men – AM System